首页 > 癌症种类 > 脑瘤 > 脑瘤症状 >

脑肿瘤的血管生成和抗血管生成治疗

2009-08-24 抗癌健康网

专注健康 关爱生命
血管生成对原发性脑肿瘤和脑转移瘤的生长、转移起关键性作用.抗血管生成治疗通过对抗肿瘤血管生成,切断肿瘤的血供,从而遏制肿瘤的生长和转移,为难以控制的恶性脑肿瘤提供了一新的治疗策略.多种脑肿瘤,特别是原发恶性脑肿瘤是人体血管活性表达最强的肿瘤,是最理想的抗血管生成治疗对象.本文对脑肿瘤血管生成及抗血管生成治疗的研究进展做一综述.

作 者:
周洪语沈建康罗其中
作者单位:
上海第二医科大学附属仁济医院神经外科,200001
刊 名:
国外医学(神经病学神经外科学分册)
英文刊名:
FOREIGN MEDICAL SCIENCES SECTION ON NEUROLOGY & NEUROSURGERY
年,卷(期):
200128(2)
分类号:
R73
关键词:
脑肿瘤 血管生成 抗血管生成
机标分类号:
R73 R74
机标关键词:
恶性脑肿瘤抗血管生成肿瘤血管生成治疗对象脑转移瘤原发性脑肿瘤治疗策略人体血管活性表达血供理想控制对抗
基金项目:
DOI:
参考文献(18条)
  1. Plate CH.Breier G.Weich HA Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors,distribution of VEGF protein and poible in vivo regulatory mechanisms 1994
  2. Plate KH Mechanisms of angiogenesis in the brain 1999
  3. Bren S.Tsanaclis AM.Gately S Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors 1992
  4. Morrison RS.Yamaguchi F.Bruner JM Fibroblast growth factor receptor gene expreion and immunoreactivity are elevated in human glioblastoma mutiforme 1994
  5. Zagzag D.Friedlander DR.Miller DC Tenascin expreion in astrocytomas correlates with angiogenesis 1995
  6. Hayes A J.Li LY.Liman ME Science, medicine, and the futrre.Antivascular therapy: a new aroach to cancer treatment 1999
  7. O‘Reilly MS.Boehm T.Shing Y Endostatin: an endogenous inhibitor of angiogenesis and tumor growth 1997
  8. Kirsch M.Straer J.Allende R Angiostatin surees malignant glioma growth in vivo 1998
  9. TanakaT.Manome Y.Wen P Viral vector- mediated traduction of a modified platelet factor 4c DNA inhibits angiogenesis and tumor growth 1997
  10. Lund EL.ang Thomsen M.Skovgaard- Poulsen H Tumor angiogenesis-a new therapeutic target in gliomas 1998
  11. Saleh M.Stacker SA.Wilks AF Inhibition of growth of C6 glioma cells in vivo by expreion of antisee vascular endothelial growth factor sequence 1996
  12. Millauer B.Longhi MP.Plate KH Dominant-negative inhibition of Flk - 1 surees the growth of many rumor types in vivo 1996
  13. Stan AC.Nemati MN.Pietsch T In vivo inhibition of angiogenesis and growth of the human U - 87 malignant glial tumor by treatment with an antibody agait basic fibroblast growth factor 1995
  14. Ramakrishnan S.Olson TA.Bautch VL Vascular endothelial growth factor- toxin conjugate ecifically inhibits KDR/flk - 1 - positive endothelial cell proliferation in vitro and angiogenesis in vivo 1996
  15. Takamiya Y.Brem H.Ojeifo J AGM- 1470 inhibits the growth of human glioblastoma cells in vitro and in vivo 1994
  16. Wilson JT.Penar PL The effect of AGM - 1470 in an improved intracranial 9L gliosarcoma rat model 1994
  17. Wolff JE.Guerin C.Laterra J Dexamethasone reduces vascular deity and plasminogen activator activity in 9L rat brain tumors 1993
  18. Valente P.Faina G.Melchiori A TIMP - 2 over - expreion reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis 1998

更多...

相似文献

病友热聊

我要提问
查看更多>>
返回首页