TRAIL/APO-2L及其受体系统在脑肿瘤中的研究进展

TRAIL/APO-2L及其受体是TNF家族中的新成员.该系统以其独特的凋亡诱导方式参与抗病毒免疫,免疫赦免以及肿瘤细胞的免疫逃逸等生理作用.TRAIL能诱导多种脑肿瘤细胞系发生凋亡而对神经细胞没有毒性,这为恶性脑肿瘤的治疗提供了新的途径.

作 者：

吴惺袁先厚袁忠惠

作者单位：

武汉大学中南医院神经外科,430071

刊 名：

国外医学（神经病学神经外科学分册）

英文刊名：

FOREIGN MEDICAL SCIENCES SECTION ON NEUROLOGY & NEUROSURGERY

年，卷(期)：

200128(4)

分类号：

R73

关键词：

TRAIL/APO-2L 受体 凋亡 脑肿瘤

机标分类号：

R28 S7

机标关键词：

受体系统肿瘤细胞系恶性脑肿瘤诱导方式生理作用神经细胞免疫逃逸免疫赦免凋亡病毒免疫治疗家族毒性

基金项目：

DOI：

参考文献(20条)

1. Wiley SR.Schooley K.Smolak PJ Identification and characterization of a new member of the TNF family that induces apoptosis 1995(6)
2. PittiRM.Marsters SA.RuertS Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family 1996(22)
3. Pan G.O‘ Rourke K.Chiaiyan AM The receptor for the cytotoxic ligan TRAIL 1997(5309)
4. Wu GS.BurTF.McDonald ER KILLER/DP5 isa DNAdamage - inducible p53 - regulated death receptor gene 1997(2)
5. Schneider P.Bodmer JL.Thome M Glaracterization of two receptors for TRAIL 1997(3)
6. PanG.Ni J.Wei YF An antagonist decoy receptor and adeath domain-containing receptor for TRAIL 1997(5327)
7. Zhang XD.Franco AV.Nguyen T Differential localization and regulation of death and decoy receptors for TNF- related apoptosis- inducing ligand (TRAIL) in human melanom cells 2000(8)
8. Yeh WC.Pompa JL.McCurrach ME FADD: Eential for embryo development and signaling from some, but not all,inducers of apoptosis 1998(5358)
9. Yzuru Imai.Takaharu Kimurs.Akira Murakami The CED-4- homologous protein FLASH is involved in Fas - mediated activation of caase - 8 during apoptosis 1999(6730)
10. Costanzo A.Guiet C.VitoP c-E10 is a caase-recruitingdomain- containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor - kaaB 1999(29)
11. Nakamura M.Rieger J.Weller M APO2L/TRAIL expreion in human brain tumors 2000(1)
12. Rieger J.Nauma U.Glaser T APO2 ligand: a novel lethal weapon agait malignant glioma? 1998(1)
13. Wu M.Das A.Tan Y Induction of apoptosis in glioma cell lines by TRAIL∥Apo- 21 2000(4)
14. Hao C.Beguinot F.CondorelliG Induction and intracellular regulationof tumor necrosis factor- related apoptosis - inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells 2001(3)
15. Eggert A.Grotzer MA.Zuzak TJ Resistance to tumor necrosis factor- related apoptosis - inducing ligand (TRAIL) - induced apoptosis in neuroblastoma cells correlates with a 1o of caase - 8 expreion 2001(4)
16. Grotzer MA.Eggert A.Zuzak TJ Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a lo of caase - 8 expreion 2000(40)
17. Roth W.Isenma S.Nauma U Locoregional Apo2L/TRAIL eradicates intracranial human malignant glioma xenografts in athymic mice in the aence of neurotoxicity 1999(2)
18. Nagane M.Pan G.Weddle JJ Increased death receptor 5 expreion by chemotherapeutic agents in human causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis - inducing ligand in vitro and in vivo 2000(4)
19. Kagawa S.He C.Gu J.Koch P Antitumor activity and bystander effects of the tumor necrosis factor -related apoptosis - inducing ligand (TRAIL) gene 2001(8)
20. Nitsch R.Bechma I.Deisz RA Human brain-cell death induced by tumour- necrosis - factor- related apoptosis - inducing ligand (TRAIL) 2000(9232)

更多...

相似文献