端粒酶与脑肿瘤关系的研究进展
2009-08-24 抗癌健康网
专注健康 关爱生命
端粒酶是一种能延长端粒的逆转录酶，近年研究表明，端粒酶活性与细胞永生化和恶变密切相关。在恶性脑肿瘤中端粒酶呈明显活化状态，很可能是一种全新的恶性脑肿瘤标志物；端粒酶活性的检测对不同类型脑肿瘤的诊断及预后判断具有较高的临床价值，以限制端粒扩增为抗癌新靶点的方法为临床脑肿瘤的治疗提供了新的思路。
- 作 者：
- 胡火军
- 作者单位：
- 湖北宜昌市中心人民医院神经外科,443003
- 刊 名：
- 国外医学(神经病学神经外科学分册)
- 英文刊名：
- FOREIGN MEDICAL SCIENCES SECTION ON NEUROLOGY & NEUROSURGERY
- 年，卷(期)：
- 200229(1)
- 分类号：
- R74
- 关键词：
- 端粒 端粒酶 脑肿瘤 肿瘤标志物
- 机标分类号：
- R73 R74
- 机标关键词：
- 端粒酶活性恶性脑肿瘤肿瘤标志物细胞永生化预后判断逆转录酶临床价值活化状态新靶点治疗诊断思路扩增抗癌检测方法变密
- 基金项目：
- DOI：
- Muller HJ The remarking of chromosome 1938
- Blackburn EH Structure and function of telomeres 1991(6319)
- Gredoer CW.Blackbum EH Identification of a tetrahymena extract 1985(43)
- Kim NW.Piatszek MA.Prowse KR ecificaociation of human telomerase activity with immortal cells and cancer 1994(5193)
- HiragaS.Ohnishi T.Izumoto S Telomerase activity and alteratio in telomere length in human brain tumors 1998(10)
- Saretzki G.Sitte N.Merkel U Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments 1999(37)
- Counter CM.Hirte HW.Bacchetti S Telomerase activity in human ovarian carcinoma 1994(8)
- Le S.Zhu JJ.Anthony DC Telomerase activity in human gliomas 1998(5)
- HaradaK.Kurisu K.Tahara H Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker 2000(4)
- Nalatani K.Yoshimi N.Mori H The significant role of telomerase activity in human brain tumors 1997(3)
- HaradaK.Kurisu K.Arita K Telomerase activity in central nervous system malignant lymphoma 1999(6)
- Langford LA.Piatyszed MA.Xu R Telomerase activity in ordinary meningiomas predicts poor outcome 1997(4)
- Zhu X.Kumar R.Mandal M Cell cycle-dependent modulation of telomerase activity in tumour cells 1996(12)
- Coon SW.Johon PC.Peral DK Prognostic significance of flow cytometry deoxyribonucleic acid analysis of human astrocytomas 1994(1)
- Shay JW.Wright WE Educational book American society of clinical oncology 1997
- Weil RJ.Wu YY.Vortmeyer AO Telomerase activity in microdiected human gliomas 1999(1)
- Mukai S.Kondo Y.Koga S 2-5A antisee telomerase RNA therapy for intracranial malignant gliomas 2000(16)
- Sawa H.Kamada H.Ohshima TA Exogenous expreion of p16INK4a is aociated with decrease in telomerase activity 1999(1)
- Carroll T.Maltby E.Brock I Meningiomas,dicentric chromosomes,gliomas,and telomerase activity 1999(4)
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