男士手指长度关系患前列腺癌风险

如果男性的食指比无名指长，他们患前列腺癌的风险会减少三分之一，其中的年轻男性患前列腺癌的风险更小。

英国癌症研究中心的罗斯教授称：“我们的研究结果表示，手指相对的长度可以用于衡量前列腺癌的风险，尤其是对于年龄小于60岁的男性。”

据她介绍，除了基因和家庭遗传因素之外，手指的长度将会帮助医生确定哪些人需要接受常规的检查。

从1994年到2005年，罗斯和她的同事调查了1500名前列腺癌患者和 3000名健康男性。

在这些前列腺癌患者中，大多数的人的食指比无名指短。而无名指和食指同样长的男性，占总调查人数的19%，患癌风险同样较大。

而对于食指较长的人，他们患前列腺癌的风险则降低33%。在这些人中，60岁以下的人，87%都不会患前列腺癌。

据介绍，这两个手指的长度，在人们出生之前就决定了，它们显示了不同水平性激素，食指越长的人睾丸素越低。而据早期的研究显示，睾丸素的多少决定患前列腺癌的风险。

对于此种相关，潜在的因素是两个基因——HOXA和HOXD，这两个基因不仅控制手指的长度还控制性器官的发展。（生物谷Bioon.com）

生物谷推荐原文出处：

British Journal of Cancer   doi: 10.1038/sj.bjc.6605986

Hand pattern indicates prostate cancer risk

A A Rahman¹, A Lophatananon², S S Brown², D Harriss³, J Anderson⁴, T Parker⁵, D Easton⁶, Z Kote-Jarai⁷, R Pocock⁸, D Dearnaley⁷, M Guy⁷, L O'Brien⁷, R A Wilkinson⁷, A L Hall⁹, E Sawyer⁷, E Page⁷, J-F Liu¹⁰, The UK Genetic Prostate Cancer Study Collaborators¹¹, British Association of Urological Surgeons' Section of Oncology¹¹, R A Eeles^7,9,12 and K Muir^2,12

1. ¹Division of Epidemiology and Public Health, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
2. ²Health Sciences Research Institute, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK
3. ³Nottingham Urology Centre, Nottingham University Hospital NHS Trust, Nottingham NG5 1PB, UK
4. ⁴Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
5. ⁵School of Biomedical sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK
6. ⁶CR-UK Genetic Epidemiology Unit, Strangeways Research Laboratories, Worts Causeway, Cambridge CB1 8RN, UK
7. ⁷The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5 NG, UK
8. ⁸Royal Devon and Exeter NHS Foundation Trust, Barrack Road, Exeter EX2 5DW, UK
9. ⁹The Royal Marsden NHS Foundation Trust, Downs Road, Sutton SM2 5PT, UK
10. ¹⁰Children's Brain Tumour Research, Division of Child Health, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK

Abstract
Background:
The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels.
Methods:
We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls.
Results:
Compared with index finger shorter than ring finger (low 2D?:?4D), men with index finger longer than ring finger (high 2D?:?4D) showed a negative association, suggesting a protective effect with a 33% risk reduction (odds ratio (OR) 0.67, 95% confidence interval (CI) 0.57–0.80). Risk reduction was even greater (87%) in age group <60 (OR 0.13, 95% CI 0.09–0.21).
Conclusion:
Pattern of finger lengths may be a simple marker of prostate cancer risk, with length of 2D greater than 4D suggestive of lower risk.
Keywords:
prostate cancer; hand pattern; case–control study